Matthew Perry was 'angry and mean' before his death due to prescribed testosterone shots, claims associate

LOS ANGELES, CALIFORNIA: Matthew Perry’s autopsy report continues to give glimpses into the last days of the ‘Friends’ actor.

The report revealed the statement of a female friend of the star who said that Perry was “angry and mean” in the weeks leading to his death because of the prescribed testosterone shots he was taking, per Page Six.

The report revealed that while Perry died from 'the acute effects of ketamine', he was also getting administered several other prescription drugs including buprenorphine, used for treating opioid addiction, Tamoxifen for weight loss, antidiabetic medication, and nicotine lollipops.

The medical examiner’s report further shed light on Perry’s life before his death as it revealed he was relying heavily on medicinal drugs.

The report noted, “In the assistant’s bedroom, there were multiple open, empty, half-filled medication bottles prescribed to the decedent, as well as over-the-counter medications, vitamins, digestive aids and dishes filled with multiple various loose pills, tablets, caplets, candy and breath mints.”

There were also “prescribed ointments, digestive aids and oral rinses” found in Perry’s bathroom.

Even though Perry was trying to quit smoking in the days leading to his passing, Perry’s live-in assistant shared that he was smoking two packs of cigarettes daily.

He was also receiving ketamine infusion therapy for depression. Still, the medical examiner determined that the ketamine found in his system could not be from the last therapy session as the effects of ketamine lasted for three to four hours, and took his therapy one-and-a-half weeks ago.

Radar Online hypothesized that Perry was receiving the testosterone shots which may have been prescribed to him to counteract the estrogen-based weight loss drug that he was also taking. 

However, the report also stated that he was clean for 19 months before his death on October 28.

'Ketamine was not for me'

Sadly enough, Perry wrote about his abhorrence for ketamine in his 2022 memoir, 'Friends, Lovers and the Big Terrible Thing', where he boldly stated that ketamine was not for him. However, as a necessary evil he accepted the drug as it was used for treating his opioid addiction and depression.

Perry, who was in a rehab in Switzerland during Covid, wrote in his memoir, "Ketamine was a very popular street drug in the 1980s. There is a synthetic form of it now, and it’s used for two reasons: to ease pain and help with depression.”

He continued, “Has my name written all over it -- they might as well have called it 'Matty,'" before adding, "Ketamine felt like a giant exhale.”

Perry went on to describe the gruelous process he had to go through in order to get the therapy and explained, “They'd bring me into a room, sit me down, put headphones on me so I could listen to music, blindfold me, and put an IV in."

There were times when he 'often thought' that 'he was dying during that hour'.

Noting that he thought “anything different is good,” Perry added, "Oh, I thought, this is what happens when you die. Yet I would continually sign up for this s--t because it was something different, and anything different is good.”

He further stated, "Taking K is like being hit in the head with a giant happy shovel. But the hangover was rough and outweighed the shovel. Ketamine was not for me."

Jennifer Aniston recounted he was 'happy' and 'healthy'

In a recent interview with Variety, Jennifer Aniston recounted texting Perry on the morning on October 28. She said, “I was literally texting with him that morning, funny Matty. He was not in pain. He wasn’t struggling. He was happy.”

Aniston also added, "He was happy. He was healthy. He had quit smoking. He was getting in shape. He was happy — that’s all I know," before reiterating, “I want people to know he was really healthy, and getting healthy. He was on a pursuit. He worked so hard. He really was dealt a tough one.”