FBI turns to Genetic Genealogy used in Golden State Killer case to hunt Nancy Guthrie suspect

This move comes after neither sample matched CODIS, the nationwide law enforcement DNA database
The FBI is using Investigative Genetic Genealogy to analyze DNA in Nancy Guthrie’s case, a method that identified Joseph James DeAngelo (FBIDirectorKash/X, savannahguthrie/Facebook)
The FBI is using Investigative Genetic Genealogy to analyze DNA in Nancy Guthrie’s case, a method that identified Joseph James DeAngelo (FBIDirectorKash/X, savannahguthrie/Facebook)

TUSCAN, ARIZONA: The same cutting-edge DNA technology that unmasked the Golden State Killer and helped book a suspect in the University of Idaho killings is now being deployed to find Nancy Guthrie’s suspected kidnappers.

The FBI confirmed on Tuesday, February 17, that Investigative Genetic Genealogy (IGG) is being used to analyze DNA found on a glove and inside Guthrie's home.

SYDNEY, AUSTRALIA - MAY 04: Australian-born presenter, Savannah Guthrie poses alongside her mother Nancy Guthrie during a production break whilst hosting NBC's
Australian-born presenter, Savannah Guthrie poses alongside her mother Nancy Guthrie during a production break whilst hosting NBC's 'Today Show' live from Australia at Sydney Opera House on May 4, 2015 in Sydney, Australia (Don Arnold/WireImage)

FBI uses genetic genealogy to track Nancy Guthrie suspect

IGG is defined as "the science of using genetic and genealogical methods to generate leads for law enforcement entities investigating crimes and identifying human remains," according to the International Society of Genetic Genealogy.

This process allows investigators to use a DNA sample to search for genetic familial matches, ultimately narrowing down potential identities by focusing on close relatives of the individual.

In simple terms, genetic genealogy is part genetics, part genealogy research, and part traditional police work. Authorities in Arizona found DNA last week belonging to someone other than Guthrie or those in close contact with her on her property.

Nancy Guthrie's residence is seen on February 10, 2026 in Tucson, Arizona. Searches continues for Nancy Guthrie, the 84-year-old mother of U.S. journalist and television host Savannah Guthrie, after she went missing from her home on the morning of February 1st. Guthrie's possible abductors had set a deadline of 5pm on February 9 for a $6 million payment. (Brandon Bell/Getty Images)
Nancy Guthrie's residence is seen on February 10, 2026 in Tucson, Arizona. (Brandon Bell/Getty Images)

Sheriff Chris Nanos of Pima County confirmed there has not been a match yet but said the DNA was collected on the day authorities first arrived at the crime scene.

Nanos said the DNA was collected from the scene the morning investigators processed Nancy’s home but declined to specify whether it was found inside or outside the house.

This move comes after neither sample found a match in the nationwide law enforcement database, CODIS, which includes only individuals previously known to authorities. IGG is not without pitfalls, as it has raised concerns about genetic privacy.

Searches can sometimes occur without police warrants, and individuals who uploaded their DNA may not have realized their genetic information could be used by law enforcement.

Joseph James DeAngelo, the suspected
Joseph James DeAngelo, the suspected 'Golden State Killer', appears in court for his arraignment on April 27, 2018 in Sacramento, California. DeAngelo, a 72-year-old former police officer, is believed to have killed at least 12 people and burglarized hundreds of homes throughout California in the 1970s and 1980s (Justin Sullivan/Getty Images)

The Golden State Killer and Idaho student deaths

This technology has helped solve some of the most infamous cold cases in history, including the Golden State Killer case.

After more than 30 years and dozens of crimes, IGG ultimately identified Joseph James DeAngelo as the man responsible for a series of crimes across California.

MOSCOW, IDAHO - MAY 22: Bryan Kohberger enters the courtroom for his arraignment hearing in Latah County District Court, May 22, 2023 in Moscow, Idaho. Kohberger is accused of killing four University of Idaho students in November 2022.
(Photo by Zach Wilkinson-Pool/Getty Images)
Bryan Kohberger enters the courtroom for his arraignment hearing in Latah County District Court, May 22, 2023 in Moscow, Idaho. Kohberger is accused of killing four University of Idaho students in November 2022 (Zach Wilkinson-Pool/Getty Images)

By matching crime scene DNA to online genetic profiles, investigators built an extensive family tree that led them to DeAngelo, a former police officer. He was arrested in 2018 and later sentenced to multiple life terms.

Following the 2022 killings of four University of Idaho students, investigators used DNA found on a knife sheath left at the scene. When traditional databases and CODIS failed to produce a match, the lab Othram created a profile that led police to Bryan Kohberger’s family in Pennsylvania.

Kohberger eventually pleaded guilty to the crime and is currently serving four consecutive life sentences.

Guthrie, 84, was last seen at her home in Pima County, near Tucson, Arizona, on Jan 31.

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