Sheriff Chris Nanos confirms DNA found at Nancy Guthrie’s home does not belong to her

Florida lab isolates unknown DNA from Nancy Guthrie’s house, helping investigators filter resident samples and focus on potential new leads
Pima County Sheriff Chris Nanos gave an update on Nancy Guthrie’s kidnapping investigation (Getty Images, Jan Sonnenmair/Getty Images)
Pima County Sheriff Chris Nanos gave an update on Nancy Guthrie’s kidnapping investigation (Getty Images, Jan Sonnenmair/Getty Images)


TUCSON, ARIZONA: DNA recovered from Nancy Guthrie’s home does not belong to her or anyone in close contact, authorities confirmed. The Pima County Sheriff’s Department said officials are now focused on identifying the unknown source of the genetic material.

Sheriff Chris Nanos the DNA as “central to the case” and crucial for ongoing investigative work. “What I believe is what I know — we found DNA, and it was not Nancy Guthrie’s,” Nanos told Fox News correspondent Jonathan Hunt. “It was not Nancy Guthrie, so we’ll continue working with the lab and doing cross-analysis. They split the samples, merge results, and it’s a complex process.”

SYDNEY, AUSTRALIA - MAY 04: Australian-born presenter, Savannah Guthrie poses alongside her mother Nancy Guthrie during a production break whilst hosting NBC's
Savannah Guthrie posed with her mother Nancy during a production break at NBC’s 'Today Show' in Sydney, 2015 (Don Arnold/WireImage)

DNA analysis isolates unknown genetic evidence

The biological samples from Guthrie’s house were sent to a Florida lab for testing. Some of the DNA belongs to residents, which helps investigators filter out known genetic material and focus on unknown samples. The multi-agency investigation continues as law enforcement works to determine the DNA’s owner.

“The investigation is detailed and ongoing,” Nanos added. “I have a team of investigators here, in a conference room filled with FBI detectives and deputies, working each day to move this forward.”

Pima County Sheriff, Chris Nanos, speaks to the media on February 3, 2026 in Tucson, Arizona. He was answering questions about the search for Nancy Guthrie, the missing mother of NBC host Savannah Guthrie.(Photo by Jan Sonnenmair/Getty Images)
Sheriff Nanos spoke to media on February 3, 2026, about the ongoing search for missing Nancy Guthrie (Jan Sonnenmair/Getty Images)

Sheriff defends handling of crime scene release

Nanos rejected criticism that the crime scene was released too quickly to the Guthrie family. Speaking to Fox News correspondent Matt Finn, he said deputies had already collected the evidence they needed and handled the site according to proper protocol. “I remain confident in the department’s decisions,” he said, emphasizing that law enforcement does not clean crime scenes before release.



The search for Nancy Guthrie has entered its 13th day. Nanos maintained that the focus remains on rescue efforts, with hope still guiding the ongoing operations.

Investigation continues amid tactical secrecy

While Nanos declined to discuss specific tactical movements in the field for safety reasons, he stressed that law enforcement continues to pursue all leads. The case remains active and high-priority, with DNA evidence potentially providing critical breakthroughs.

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