Christina Applegate reveals new health struggle after MS misdiagnosis: 'Back at square one'

In her health update in October, Christina Applegate clarified that she continues to experience debilitating symptoms despite her MS misdiagnosis
Christina Applegate has opened up about struggling with her identity following her multiple sclerosis (MS) misdiagnosis (Getty Images)
Christina Applegate has opened up about struggling with her identity following her multiple sclerosis (MS) misdiagnosis (Getty Images)

LOS ANGELES, CALIFORNIA: Christina Applegate is facing another difficult chapter in her health journey after learning that she was misdiagnosed with multiple sclerosis (MS).

The actress, who believed she had been living with the condition since 2021, is now undergoing tests to find out what is causing her symptoms. During a recent episode of her podcast, 'MeSsy', Applegate also opened up about the emotional toll of losing a diagnosis that had shaped her life for years.

Christina Applegate attends the 29th Annual Screen Actors Guild Awards at Fairmont Century Plaza on February 26, 2023 in Los Angeles, California (Getty Photos | Axelle/Bauer-Griffin)

Christina Applegate undergoes tests for other health conditions

On the November 3 episode of 'MeSsy', which she co-hosts with Jamie-Lynn Sigler, Applegate discussed her latest medical updates while speaking with guest Jack Osbourne. She explained that doctors are now investigating other conditions that can cause symptoms similar to those of MS.

“We’re going in to square one, just doing some testing and going one by one of kind of the sister diseases to MS,” she said. The actress named rheumatoid arthritis, lupus and Lyme disease as some of the conditions doctors are checking for.

“You’ve got RA (rheumatoid arthritis), and you’ve got lupus and Lyme disease and all these things that kind of can mimic MS,” she explained. “So, now I’m being tested for all that stuff, slowly but surely.”

Christina Applegate attends the 25th Annual Critics' Choice Awards at Barker Hangar on January 12, 2020 in Santa Monica, California (Getty Photos/Emma McIntyre)

Applegate, 54, revealed in October that her doctor had told her she did not have MS, despite receiving the diagnosis in 2021.

Apart from the physical challenges, Applegate admitted that adjusting to life without the diagnosis has been difficult. She explained that MS had become a major part of her identity, making it hard to process the change.

Christina Applegate vows to fight for the MS community despite misdiagnosis

During the October 27 episode of her 'MeSsy' podcast, Applegate said, “Even though I don’t have this disease, I’ve fallen in love with everyone that we know, our listeners, our friends that have MS."

"I’m still your warrior, and I’m still going to speak out on your behalf forever and ever. Despite not having MS, I still feel like part of this community. No matter what, I love you."

During the same podcast episode, she also opened up about how everyday tasks have become increasingly difficult for her over the years.

Christina Applegate poses before attending the 75th Primetime Emmy Awards on January 15, 2024 in Los Angeles, California (Getty Photos/John Shearer)

“I actually timed it today; it took me 10 minutes to be able to move off my pillow and get out of the bed and stand up, at which point I almost couldn’t walk to the bathroom, and now a walker is sitting next to my bed because of what’s going on. I don’t know what’s going on," she shared.

GET BREAKING U.S. NEWS & POLITICAL UPDATES
STRAIGHT TO YOUR INBOX.

MORE STORIES

The English actor also stated that just being among the people currently considered to be in the running for next James Bond role “is extraordinary.”
2026-11-04T08:12:02.000Z
Dench also revealed that she still reaches for the phone to call Maggie Smith before remembering her late friend is gone.
2026-11-04T07:18:14.000Z
Walter Koenig's rep said in a statement on Oct 26 that he died 'of old age at home in North Hollywood last night surrounded by his daughter and niece'
2026-11-04T07:03:30.000Z
The designer criticized Justin Timberlake’s documentary for revisiting the controversy without involving him, despite designing Janet Jackson’s outfit
2026-11-04T06:46:43.000Z
Blac Chyna faced a $116,732 tax lien for 2024, years after Rob Kardashian stopped paying $20,000 in monthly child support
2026-11-04T04:57:04.000Z
Pierce Brosnan said he was eagerly awaiting the next 007 announcement and admired all the actors linked to the role
2026-11-04T04:47:58.000Z
Richard Kline praised John Ritter's widow for her continued efforts to educate people about aortic dissection over the past two decades
2026-11-04T04:19:51.000Z
The 80-year-old singer-actress was honored with the Best Actress Academy Award for her movie ‘Moonstruck’ in the 1988 Oscars.
2026-11-04T04:19:23.000Z
Rebecca Gayheart filed for divorce from Eric Dane in 2018 but withdrew the petition in March 2025 as they continued raising their daughters together
2026-11-04T04:03:57.000Z
In a recent court filing, Paris said the trust has received no money for more than 17 years, even though the estate has made billions of dollars since her father died in 2009
2026-11-04T03:27:16.000Z