Nick Reiner’s weight gain and medication change fueled parents’ killings, documentary claims

Reports mentioned that Nick Reiner’s mental state worsened after a medication change weeks before he killed his parents, Rob and Michelle Reiner
Sources say Nick Reiner was diagnosed with schizoaffective disorder around 2020 and remained stable for years while medication helped manage his symptoms (Laura Cavanaugh/FilmMagic)
Sources say Nick Reiner was diagnosed with schizoaffective disorder around 2020 and remained stable for years while medication helped manage his symptoms (Laura Cavanaugh/FilmMagic)

LOS ANGELES, CALIFORNIA: The unraveling of Nick Reiner, which ended with the shocking killings of his parents, Rob and Michelle Reiner, may trace back to a decision made just weeks earlier, when concerns about weight gain led to a change in his psychiatric medication, sources familiar with the case told TMZ.

The new details emerged as part of TMZ’s latest documentary, 'The Reiner Murders: What Really Happened,' which examines Reiner’s long struggle with mental illness, substance abuse, and the series of events that culminated in the double homicide.

According to multiple sources with direct knowledge, Reiner’s mental state deteriorated rapidly after doctors altered the medication that had kept him stable for years.

Nick Reiner attends AOL Build Speaker Series at AOL Studios In New York on May 4, 2016 in New York City. (Photo by Laura Cavanaugh/FilmMagic)
Nick Reiner attends AOL Build Speaker Series at AOL Studios In New York on May 4, 2016 in New York City (Laura Cavanaugh/FilmMagic)

Nick Reiner’s schizoaffective disorder diagnosis and years of treatment

Sources say Nick Reiner was diagnosed around 2020 with schizoaffective disorder, a serious mental illness marked by delusions, hallucinations, mania, and deep depression. For years, medication reportedly helped manage his symptoms and kept him grounded in reality.

Rob Reiner and Nick Reiner attend AOL Build Speaker Series at AOL Studios In New York on May 4, 2016 in New York City. (Photo by Laura Cavanaugh/FilmMagic)
Rob Reiner and Nick Reiner attend AOL Build Speaker Series at AOL Studios In New York on May 4, 2016 in New York City (Laura Cavanaugh/FilmMagic)

That stability, however, came at a cost. Reiner allegedly struggled with significant weight gain, a known side effect of some psychiatric medications and voiced growing frustration to his doctors. Those concerns, sources say, prompted a change in his treatment plan roughly a month before the murders.

Medication change triggered rapid and dangerous mental decline

According to people familiar with the case, the switch proved catastrophic. The new medication allegedly sent Reiner into an increasingly erratic and unstable state, with his behavior becoming more alarming as days passed.

LOS ANGELES, CA - JUNE 20: Director Rob Reiner (L) and wife Michele Singer attend the premiere of
Director Rob Reiner and wife Michele Singer attend the premiere of 'The Magic of Belle Isle' at the Directors Guild of America on June 20, 2012 in Los Angeles, California (David Livingston/Getty Images)

Sources say Rob and Michelle noticed the dramatic change in their son and were deeply concerned, but felt uncertain about how to intervene. Despite the escalating warning signs, doctors did not place Reiner on a temporary psychiatric hold - an option that could have allowed authorities to detain him for up to 14 days to stabilize his condition.

By the time of the killings, sources say Reiner had experienced a complete break from reality.

Parents were aware of warning signs but felt powerless

Those close to the family say Rob and Michelle were not in denial about their son’s condition. They reportedly understood that something was terribly wrong, but lacked the authority or guidance to force treatment.

LOS ANGELES, CA - AUGUST 09: Actor/Producer/Director Rob Reiner (center) and wife Michele Singer (L) and son Nick Reiner (R) attend Teen Vogue's Back-to-School Saturday kick-off event at The Grove on August 9, 2013 in Los Angeles, California. (Photo by Michael Buckner/Getty Images for Teen Vogue)
Actor/Producer/Director Rob Reiner and wife Michele Singer and son Nick Reiner attend Teen Vogue's Back-to-School Saturday kick-off event at The Grove on August 9, 2013 in Los Angeles, California (Michael Buckner/Getty Images for Teen Vogue)

The absence of a temporary psych hold has since become a point of quiet but profound scrutiny among those following the case, particularly given how abruptly Reiner’s mental health deteriorated after years of relative stability.

Legal defense centers on insanity and competency concerns

As previously reported, Nick’s legal team planned to pursue a plea of not guilty by reason of insanity, a position his now-former attorney, Alan Jackson, strongly suggested following a recent court hearing.

LOS ANGELES, CALIFORNIA - DECEMBER 17: Alan Jackson, attorney of Nick Reiner, appears in court to defend Reiner on murder charges on December 17, 2025 in Los Angeles, California. The LAPD confirmed that Rob Reiner and his wife Michele Singer Reiner were found dead in their Brentwood home. Their son Nick was arrested in connection with their deaths and is charged with two counts of first-degree murder, according to the Los Angeles County district attorney. (Photo by Jae C. Hong-Pool/Getty Images)
Alan Jackson, attorney of Nick Reiner, appears in court to defend Reiner on murder charges on December 17, 2025 in Los Angeles, California (Getty Images)

Multiple sources now tell TMZ that Nick is not competent to stand trial. Behind bars, he is said to understand that he killed his parents, yet remains convinced that his incarceration is the result of a conspiracy against him rather than his own actions.

Those close to the situation describe a man still deeply disconnected from reality, trapped in delusions even as the legal system moves forward.

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