Rosie O'Donnell stuns with dramatic weight loss transformation after using Mounjaro: 'I can’t believe'

Rosie O'Donnell shared a picture of her weight loss from Mounjaro more than two years after revealing she was taking the type 2 diabetes drug
PUBLISHED MAY 25, 2025
Rosie O'Donnell is in disbelief with her dramatic weight loss journey (Rosie O'Donnell/Instagram, Getty Images)
Rosie O'Donnell is in disbelief with her dramatic weight loss journey (Rosie O'Donnell/Instagram, Getty Images)

DUBLIN, IRELAND: Not just her fans but Rosie O'Donnell herself can’t believe her dramatic weight loss transformation.

The 63-year-old TV personality left many jaws dropped as she debuted her new, slender figure in an Instagram post on Friday, May 23. “I can't believe this is me now,” she captioned a slimmed-down photo of herself, adding the hashtags “#mounjaro, #weightloss” and “#bodydismorphia.”

In her post, she was seen wearing dark pants and a light green sweater as she held a mic and a mic stand while appearing to talk to the audience.

‘The View’ alum didn't give any context for the shot, but many fans assumed it was from a stand-up show in Ireland, where O’Donnell moved with her child, Clay, following President Donald Trump’s election.


 
 
 
 
 
View this post on Instagram
 
 
 
 
 
 
 
 
 
 
 

A post shared by Rosie O’Donnell (@rosie)


 

Rosie O'Donnell opens up about her experience with Mounjaro

The 'A League of Their Own' star first spoke about her 'shocking' new size in March after taking the Mounjaro to manage her diabetes, according to Daily Mail.

Mounjaro (tirzepatide) is a type 2 diabetes and weight loss drug, similar to Ozempic and Wegovy. Several celebrities, including Elon Musk, Meghan Trainor, and her husband Daryl Sabara, have recently admitted to using the drug.

NEW YORK, NY - MAY 04: Rosie O'Donnell attends the 30th Annual GLAAD Media Awards at New York Hilton Midtown on May 4, 2019 in New York City. (Photo by Taylor Hill/Getty Images)
Rosie O'Donnell attends the 30th Annual GLAAD Media Awards at New York Hilton Midtown on May 4, 2019, in New York City (Taylor Hill/Getty Images)

"I am on Mounjaro for my diabetes, and one of the side effects is you lose weight," O’Donnell explained in tiktok uploaded at that time. "But [the weight loss] is also because I had a chef for over two years in Los Angeles, and I don't have a chef now. It's me cooking for [my child] Clay and me."

O’Donnell then described how she went to a clothing store in Dublin where she discovered she was a size large after previously wearing XL or XXL. "I find it shocking. I really do. I find it completely shocking," the mom-of-five expressed.


 
 
 
 
 
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A post shared by Rosie O’Donnell (@rosie)


 

Being on Mounjaro has not only helped her lose weight, but it has also made her feel "healthier and sleeping better."

In January 2023, O'Donnell claimed that she had lost 10 pounds after taking the pill during the holiday season after her doctor prescribed it.

"I need to let you know I've lost 10lbs since Christmas," she said, adding she has been taking Mounjaro after a fan commented, ''You can't drop a bomb like that and not tell us HOW???'


@rosie Replying to @yogurtexperience ♬ original sound - Rosie ODonnell

 

"Okay, so like two months ago, my doctor put me on... not Ozempic, Mounjaro? Something like that, and Repath," she continued. "One I do every other week, and one I do once a week. And that and on Christmas, I stopped drinking anything except water."

‘'Now I have had champagne one night, that was a toast, and some wine one night, so it hasn't been 100% but I really stopped drinking like five or six Diet Cokes a day," the TV personality continued.


 
 
 
 
 
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A post shared by Rosie O’Donnell (@rosie)


 

Fans praise Rosie O'Donnell for her dramatic transformation

Rosie O'Donnell’s fans praised the TV personality after she debuted her slimmer figure on Instagram. "

Good for you, Rosie!!!! Shine ON!" one user commented under her post.

"You look fantastic, Ro!" another user praised, while one said, "Im happy for your weight loss for better health. The bad thing about monjaro is some people take it too far, and they all get a gaunt-looking face."

"She looks 20 years older…" one person wrote.

"Way to go, lady! I’m sure you feel so much better. I know it’s a struggle. You look great!" one more said.

"Looking great. And look at you doing stand-up in Ireland. Literally back to your roots," another one commented.

This article contains remarks made on the Internet by individual people and organizations. MEAWW cannot confirm them independently and does not support claims or opinions being made online.

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